Zinc Deficiency, Excess and Supplementation
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چکیده
It is an essential component/cofactor for more than 300 enzymes involved in the synthesis and metabolism of carbohydrates, lipids, proteins, nucleic acids and other micro-nutrients. It stabilises cellular components and membranes and so is important for cell and organ structure and integrity. It is essential for cell division and is needed for normal growth and development during pregnancy, childhood and adolescence. It is involved in DNA synthesis and the process of genetic expression. It is important for immune function (both cellular and humoral immunity). It is involved in wound healing and tissue repair. It is needed for the senses of taste and smell.
منابع مشابه
Effect of zinc and iron supplementation on vitamin A status of primary school children
Background: Micronutrients deficiency is one of the most health problems in the world. Iron and zinc deficiency and their interaction with vitamin A are important, too. The aim of this study was to investigate the effects of supplementation of iron and zinc, alone or combined, on vitamin A status of primary school children. Material and methods: The study was a randomized double-blind clinica...
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Background: Thalassemia constitutes a major public health problem causing a significant burden on children and their families. Zinc deficiency plays an important role in many thalassemia-related complications like growth retardation, hypogonadism and delayed puberty which are frequently noted in adolescent age. Although zinc is supplemented to thalassemic patients visiting Day Care Center, Yang...
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BACKGROUND Chronic, excess zinc intake can result in copper deficiency and profound neurologic disease. However, when hyperzincemia is identified, the source often remains elusive. We identified four patients, one previously reported, with various neurologic abnormalities in the setting of hypocupremia and hyperzincemia. Each of these patients wore dentures and used very large amounts of dentur...
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In this special issue about biofactors causing cognitive impairment, we present evidence for and discuss two such biofactors. One is excess copper, causing neuronal toxicity. The other is zinc deficiency, causing neuronal damage. We present evidence that Alzheimer's disease (AD) has become an epidemic in developed, but not undeveloped, countries and that the epidemic is a new disease phenomenon...
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Copper deficiency is a rare cause of sideroblastic anemia and neutropenia that often is not suspected clinically. The morphologic findings in bone marrow, while not pathognomonic, are sufficiently characteristic to suggest the diagnosis, leading to further testing to establish the correct diagnosis. Excess zinc ingestion is among the causes of copper deficiency. We present 3 cases of zinc-induc...
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Zinc deficiency is widespread and tends to mirror the distribution of infectious diseases prevalent in the developing world. Despite numerous observational studies suggesting a key role for zinc in human immunity and an involvement in disease pathogenesis, the underlying mechanisms remain poorly understood, and zinc intervention trials across a range of diseases have yielded mixed results. Ther...
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